National Institutes Of Health

February 23, 2026 ADVOCATE ISO, ARPA-H-SOL-26-142, Amendment 02: The purpose of ARPA-H-SOL-26-142, Amendment 02 is to revise the following sections as shown in the highlighted text: Table of Contents TA1: CVD Agent – Reliable Agentic Care Management under Section 1.2.1 Technical Areas…

The Advanced Research Projects Agency for Health (ARPA-H) is posting this Innovative Solutions Opening (ISO) solicitation in support of the Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Program. ARPA-H anticipates that multiple Other Transaction (OT) Agreements will result from…

This Special Notice (SN) provides information about the ARPA-H CIRCLE Program Proposers’ Day (PD) on Wednesday, March 11, 2026. ARPA-H published an Innovative Solutions Opening (ISO) solicitation for the CIRCLE program on February 17, 2026. The CIRCLE ISO (ARPA-H-SOL-26-139) is posted on…

The Advanced Research Projects Agency for Health (ARPA-H) is posting this Innovative Solutions Opening (ISO) solicitation in support of the Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Program. ARPA-H anticipates that multiple Other Transaction (OT) Agreements will result from…

Amendment 3 : The purpose of this amendment is to amend the Attachments. Changes to the attachments are listed below: Attachment 3 Cost Proposal Narrative: references to "lead organization" were changes to "lead member." See red text on the cover page. Attachment…

02/06/2026 – This SN amendment provides updated information related to the BIOGAMI Proposers’ Day and provides the BIOGAMI_Lightning Talk Template. Please review the attached BIOGAMI_SN_ARPA-H-SN-26-147_Amendment 1 for details. Changes are reflected in red text within the attachment. _________________________________________________________________ This Special Notice (SN)…

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This Special Notice (SN) is intended to alert the scientific community to an Advanced Research Projects Agency for Health (ARPA-H) Program and notify potential proposers of the ADVOCATE Question and Answer (Q&A) Webinar. The Scalable Solutions Office (SSO) is sponsoring a non-mandatory…

February 5, 2026 ADVOCATE ISO, ARPA-H-SOL-26-142, Amendment 01: The purpose of ARPA-H-SOL-26-142, Amendment 01 is as follows: Make a correction to Table 7 – Performer Collaboration Expectations under Section 1.2.5 Performer Collaboration Expectations (See highlighted text). Revise the last paragraph under Section…

This Special Notice (SN) alerts the scientific community to a newly approved ARPA-H program and notifies potential proposers of an associated Proposers’ Day. See attached BIOGAMI_SN_ARPA-H-SN-26-147 for further details.

The Advanced Research Projects Agency for Health (ARPA-H) is posting this Innovative Solutions Opening (ISO) in support of the BIOmolecular Grammar for protein Aggregation Modulation and Intervention (BIOGAMI) Program. ARPA-H anticipates that multiple Other Transaction (OT) Agreements will result from this announcement.…

Amendment 2 : The purpose of this amendment is to amend the BoSS ISO. An updated version of the ISO, with changes in red font, is included as an attachment to this amendment. Changes to the ISO include (but are not limited…

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The BioStabilization Systems (BoSS) program aims to transform how live cell-based therapies are stabilized, manufactured, and distributed. At its core, BoSS addresses a foundational bottleneck in the delivery of advanced cell and gene therapies (CGTs): the critical dependence on ultra-cold conditions (-80…

MOCS ISO(ARPA-H-SOL-26-143) posted to SAM.GOV, November 13, 2025. MOCS ISO (ARPA-H-SOL-26-143) Amendment 01 posted to SAM.GOV, December 16, 2025. For details, please see the Summary of Changes (pg 2) in the attached (MOCS_ISO_Amend_01_ 20251216). MOCS ISO (ARPA-H-SOL-26-143) Amendment 02 posted to SAM.GOV,…