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Department of Health and Human Services

Treating Hereditary Rare Diseases With In Vivo Precision Genetic Medicines (THRIVE)

Solicitation: ARPA-H-SOL-25-122
Notice ID: e2dfbdba502742c480b847d537e78e72

Solicitation from NATIONAL INSTITUTES OF HEALTH • HEALTH AND HUMAN SERVICES, DEPARTMENT OF. Place of performance: DC. Response deadline: Feb 05, 2026. Industry: NAICS 541714 • PSC AN13.

Market snapshot

Baseline awarded-market signal across all contracting (sample of 400 recent awards; refreshed periodically).

12-month awarded value
$659,327,406
Sector total $659,327,406 • Share 100.0%
Live
Median
$157,798
P10–P90
$29,611$1,830,899
Volatility
Volatile200%
Market composition
NAICS share of sector
A simple concentration signal, not a forecast.
100.0%
share
Momentum (last 3 vs prior 3 buckets)
+100%($659,327,406)
Deal sizing
$157,798 median
Use as a pricing centerline.
Live signal is computed from awarded notices already observed in the system.
Signals shown are descriptive of observed awards; not a forecast.

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Live POP
Place of performance
Washington, District of Columbia • 20005 United States
State: DC
Contracting office
Washington, DC • 20005 USA

Point of Contact

Name
THRIVE PROGRAM
Email
THRIVE@arpa-h.gov
Phone
Not available

Agency & Office

Department
HEALTH AND HUMAN SERVICES, DEPARTMENT OF
Agency
NATIONAL INSTITUTES OF HEALTH
Subagency
ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H)
Office
Not available
Contracting Office Address
Washington, DC
20005 USA

More in NAICS 541714

Description

https://api.sam.gov/prod/opportunities/v1/noticedesc?noticeid=e2dfbdba502742c480b847d537e78e72

Files

Files size/type shown when available.

BidPulsar Analysis

A practical, capture-style breakdown of fit, requirements, risks, and next steps.

Updated: Jan 10, 2026
Executive summary

The THRIVE program under ARPA-H is focused on the treatment of hereditary rare diseases using in vivo precision genetic medicines. It seeks innovative solutions through research and development and aims to leverage advanced genetic technologies for effective therapeutic strategies. This initiative represents a unique funding opportunity for organizations specializing in genetic medicine, biotechnology, and rare diseases.

What the buyer is trying to do

The buyer is aiming to solicit proposals that develop precision genetic medicines targeting hereditary rare diseases. The objective is to advance scientific understanding and applications of genetic therapies that can transform patient outcomes.

Work breakdown
  • Understanding the requirements of in vivo precision genetic medicines
  • Developing a comprehensive research proposal
  • Demonstrating expertise in hereditary rare diseases
  • Creating a solid project plan
  • Outlining milestones and deliverables for the proposed solution
Response package checklist
  • Cover letter
  • Business proposal outlining approach and team expertise
  • Research plan with timelines
  • Budget outline and funding justification
  • Compliance documentation related to genetic research
Suggested keywords
genetic medicinehereditary rare diseasesin vivo therapiesbiotechnologyprecision medicineNIH fundingtherapeutic development
Source coverage notes

Some notices publish limited source detail. Confirm these points before final bid/no-bid decisions.

  • Specific requirements or guidelines for proposal format
  • Evaluation criteria used by the selection committee
  • Detailed timeline for proposal review and selection process
  • Budget cap or funding limits for proposals
  • Expected range of project duration before outcomes are realized

FAQ

How do I use the Market Snapshot?

It summarizes awarded-contract behavior for the opportunity’s NAICS and sector, including a recent pricing band (P10–P90), momentum, and composition. Use it as context, not a guarantee.

Is the data live?

The signal updates as new awarded notices enter the system. Always validate the official award and solicitation details on SAM.gov.

What do P10 and P90 mean?

P10 is the 10th percentile award size and P90 is the 90th percentile. Together they describe the typical spread of award values.